Observation of therapeutic effect and toxic reaction of CFC regimen chrono-chemotherapy in treatment of oral and maxillofacial squamous cell carcinoma

doi:10.3877 / cma.j.issn.1674-1366.2009-04-011

Abstract

Abstract:

Objective

To evaluate therapeutic effect and toxic recation of CFC regimen chrono-chemotherapy in the treatment of maxillofacial squamous cell carcinoma.

Methods

15 cases of maxillofacial squamous cell carcinoma were all treated by the CFC medicine project（Carboplatin； 5-Fluorouracil； Calcium Folinate）. The Chrono-chemotherapy medicine was administrated from 16：00 to tomorrow 7：00. Therapeutic effect and toxicities were observed. The operation was performed in 10～ 21 days after chemotherapy.

Results

After chemotherapy，complete response （CR） was achieved in 3 case， partial response （PR） in 11 cases and no nesponse （NR） in 1 case. The overall response rate （CR+PR） was 93.3%. the Chrono-chemotherapy medicine has lower toxicities incidence rate， such as nausea， vomiting， descending WBC and RBC.

Conclusion

Chrono-chemotherapy， which has lower toxicities incidence， was potentially recommended for clinical application.

Key words: Squamous cell carcinoma, CFC project, Chrono-chemotherapy, Toxic recation

Yun-hua YOU, Jun LIANG, Yue-ping WANG, Yong-feng LIN, Hua-wei ZHANG, Xuan XIAO. Observation of therapeutic effect and toxic reaction of CFC regimen chrono-chemotherapy in treatment of oral and maxillofacial squamous cell carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2009, 3(04): 414-418.

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Figures/Tables 4

References 7

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术式	例数
下颌骨骨段切除并髂骨修复及颈淋巴清扫术	4
舌癌切除并前臂皮瓣舌再造及颈淋巴清扫术	5
舌癌切除并胸大肌皮瓣修复舌再造及颈淋巴清扫术	2
口底癌切除并胸大肌皮瓣修复及颈淋巴清扫术	1

术式	例数
下颌骨骨段切除并髂骨修复及颈淋巴清扫术	4
舌癌切除并前臂皮瓣舌再造及颈淋巴清扫术	5
舌癌切除并胸大肌皮瓣修复舌再造及颈淋巴清扫术	2
口底癌切除并胸大肌皮瓣修复及颈淋巴清扫术	1

病理类型	例数	疗效（n）			CR+PR（%）
病理类型	例数	CR	PR	NR	CR+PR（%）
高分化鳞癌	11	3	7	1	90.1
低分化鳞癌	4	0	4	0	100.0
合计	15	3	11	1	93.3

病理类型	例数	疗效（n）			CR+PR（%）
病理类型	例数	CR	PR	NR	CR+PR（%）
高分化鳞癌	11	3	7	1	90.1
低分化鳞癌	4	0	4	0	100.0
合计	15	3	11	1	93.3

发病部位	例数	疗效（n）			CR+PR（%）
发病部位	例数	CR	PR	NR	CR+PR（%）
舌	8	2	6	0	100.0
牙龈	3	0	3	0	100.0
下颌骨	2	0	1	1	50.0
口底	2	1	1	0	100.0
合计	15	3	11	1	93.3

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